SSI DiagnosticaHerredsvejen 23400 HillerødDENMARKT: (+45) 48 29 91 00EAN: 5790 002327452VAT: 37294535
Pneumococci produce a conserved sugar group antigen (CWPS, C-Ps, teichoic acid).
CWPS-like sugars are found also on the oral streptococci S. mitis and S. oralis. Since humans are constantly affected by oral streptococci and non-invasive pneumococci (carriers), humans normally have a high level of non-protective antibodies against CWPS.
Streptococcus pneumoniae expresses a number of different sugars on the cell surface. Most sugars are in the cell capsule, which defines the 91 different pneumococcal serotypes currently known. In addition to the type-specific capsule sugars, all pneumococci also express a group antigen, referred to as the cell wall polysaccharide (CWPS). CWPS is found in two different forms, depending on the quantity of phosphorylcholine per sugar unit. The capsule sugars are found in existing vaccines, partly in conjugate vaccine for children, but also in pure sugar vaccines for adults.
Pneumococcal CWPS are produced by purifying the sugar from a non-capsule-bearing pneumococcus. The protein and DNA/RNA impurity is minimal, less than 3% of the total quantity.
Pneumococcal CWPS is used as adsorption material in immunological investigations such as ELISA antibody assays, to evaluate whether any vaccination/revaccination is desirable.
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